Kurt Busch dominated much of the race but lost the lead during a round of cautionary pit stops to Kyle, who took the lead on a restart with 23 laps of 267 remaining.
Kurt fell back to fourth place before storming forward again. After Larson knocked Kyle out for the lead on the restart, Kurt caught up to Kyle on lap 237 for second.
From there, Kurt patiently gained ground on Larson and dived into him at Turn 3 with eight laps to go to retake the lead. He outpaced Larson by 1.413s to take the win – his first of the 2022 season.
The win is Busch’s first as a member of 23XI Racing, owned by NBA legend Michael Jordan and Cup driver Denny Hamlin, and second for the organization.
Busch, 43, ended up leading at race level with 116 laps and appeared to have the fastest car in the race. But a host of tire problems and pit lane errors – not to mention fighting side-by-side with Larson – left the outcome in doubt until the end.
“It’s about teamwork. I’m not doing it alone,” said Busch, who celebrated his 34th career win. “The way Toyota has helped us and (Joe Gibbs Racing) and my little brother has been so important on the family side right now. Bubba was a great teammate.
“This is our first win for the #45 car and with the Jordan Brand on the hood I felt like I had to win like the GOAT, race like the GOAT and beat Kyles. I beat both of them – The Kyle and Kyle Show.
“This #45 car is now a winner!”
When asked what the work is like getting a new team into victory lane so late in his career, Busch said: “Working from the ground up with a brand new car is the most satisfying. Everyone at 23XI – this is for us. That’s what the hard work is about.”
Kyle Busch was third, Hamlin fourth and pole winner Christopher Bell rounded out the top five.
Completing the top-10 were Martin Truex Jr., Ross Chastain, Ricky Stenhouse Jr., Alex Bowman and Kurt Busch’s teammate Bubba Wallace, who was recovering from a pit lane penalty.
After the break between stages 2 and 3, all cars on the lead lap with Kurt Busch drive the first off-pit lane to the pits.
Kyle Busch was penalized for speeding during his stop and had to restart from the back of the field, as did Truex, who was penalized for pitting too early.
At the restart on lap 174, Kurt Busch was followed by Ryan Blaney, Larson and Austin Cindric.
With 80 laps to go Hamlin – who had been plagued by problems throughout the race – had moved up to third place and was challenging Larson for second. Kurt Busch continued to lead the way.
Chase Elliott spun off the track at Turn 3 and got stuck in the infield grass to earn the seventh caution of the race on lap 197.
All lead lap cars pit with Kurt Busch off pit lane first. Wallace, riding in the top five, was penalized for an uncontrolled tire and had to restart at the back of the field. Kevin Harvick was penalized for speeding and also had to restart from the back.
The race returned to green on lap 202 with Kurt Busch in the lead followed by Larson, Blaney and Hamlin.
Larson and Kurt Busch fought side-by-side after the restart and traded the lead only to see Kurt Busch return to the lead on Lap 204.
NASCAR issued a warning on lap 230 for possible liquid on the track. The lead lap cars all take the first off pit lane with Kyle Busch.
At the restart on lap 235, Kyle Busch was leading, followed by Larson, Kurt Busch, Bell and Hamlin.
Larson went inside Kyle Busch at Turn 3 and walked away with the lead.
With 21 laps to go, Kurt Busch passed Kyle and moved up to second behind leader Larson.
With eight laps to go, Kurt Busch went inside Larson at Turn 3 and retook the lead at Turn 4.
Kurt Busch held off his younger brother Kyle by 1.1 seconds and took the win on stage two.
Truex, who was fourth, hit the wall and got a flat tire and fell off pace on the final lap. Blaney was third, Cindric fourth and Elliott rounded out the top five.
After the break between Stages 1 and 2, all cars on the first lap pit with Elliott taking the first off pit road. Kyle Busch brought his No. 18 Toyota too close to the pit wall during his stop, resulting in him losing nine places down the pit lane.
Elliott and Hamlin were both penalized for interfering with equipment at their stops and both had to restart from the back of the field, as did Wallace for getting a crewman over the wall early.
When racing resumed on lap 88, Chastain was leading, followed by Truex and William Byron.
Byron dove into both Chastain and Truex in the restart to take the lead for the first time.
On lap 113, Byron had a puncture on the left rear wheel, marking the wall that allowed Kurt Busch to take the lead. Byron had to pit under green. He returned to the race two laps down.
Tyler Reddick hit the wall in turn 1 on lap 117 and had to pit for repairs under green as well.
Truex was among the first of the leaders to pit on lap 123 to initiate a round of green flag pit stops.
In the middle of the stops, Harvick spun at Turn 1 after exiting the pit lane, resulting in a caution. Elliott was declared the leader of the race when the caution was indicated.
Those who were not yet in the pits did so under caution with Kurt Busch on the first off-pit lane. The race returned to green on lap 137.
With 10 laps to go, Kurt Busch held a 1.3 second lead over Kyle Busch while Blaney was third.
Kyle Busch held off Chastain in the final 13 laps after a late restart to take the first stage win, his first of the 2022 season.
Elliott was third, Reddick fourth and Byron rounded out the top five.
Bell started from pole and took charge early, but Chase Briscoe spun at Turn 4 on Lap 6 to give the race an early warning.
The race returned to green on lap 10 with Bell still ahead followed by Reddick, Larson and Cindric.
Reddick quickly got past Bell on the restart to take the lead.
On Lap 34 Larson got around Reddick and took the lead just before BJ McLeod spun out of Turn 4 and went down the front straight.
The lead lap cars all take the first off pit lane with Bell. Cindric (uncontrolled tire), Austin Dillon (equipment removal) and Hamlin (equipment malfunction) all had to restart from the back of the field.
At the restart on lap 41, Bell led the way, followed by Reddick, Kyle Busch and Daniel Suarez.
Suarez spun at Turn 4 on Lap 62 and just got a piece of the wall to issue a caution. Bell, the leader, under caution cut off a left rear tire.
Most of the lead lap cars all pit first outside of the pit lane, thanks to a two tire pit stop. Stenhouse, one of those who stayed out, led the restart on lap 68. Jones finished fourth.
Kyle Busch got off to a good restart and took the lead for the first time in the race.
With five laps to go, Kyle Busch held a slight lead over Chastain while Elliott was third.
Five drivers had to start the race from the back of the field – Hamlin, Todd Gilliland and Stenhouse due to unauthorized adjustments and Chris Buescher and Joey Logano due to swapping to spare cars.